Binding Properties of a Peptide Derived from β-Lactamase Inhibitory Protein

To overcome the antibiotic resistance mechanism mediated by β-lactamases, small-molecule β-lactamase inhibitors, such as clavulanic acid, have been used. This approach, however, has applied selective pressure for mutations that result in β-lactamases no longer sensitive to β-lactamase inhibitors. On...

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Bibliographic Details
Main Authors: Rudgers, Gary W., Huang, Wanzhi, Palzkill, Timothy
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC90827/
https://ncbi.nlm.nih.gov/pubmed/11709298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.12.3279-3286.2001
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