Selection and Genetic Characterization of Streptococcus pneumoniae Mutants Resistant to the Des-F(6) Quinolone BMS-284756

Existing quinolones are known to target the type II topoisomerases in bacteria. In order to determine which of these targets are of key importance in Streptococcus pneumoniae treated with BMS-284756 (T-3811ME), a novel des-F(6) quinolone, resistant mutants were selected in several steps of increasin...

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Bibliografiska uppgifter
Huvudupphovsmän: Hartman-Neumann, Sandra, DenBleyker, Kenneth, Pelosi, Lenore A., Lawrence, Laura E., Barrett, John F., Dougherty, Thomas J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2001
Ämnen:
Mechanisms of Resistance
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC90744/
https://ncbi.nlm.nih.gov/pubmed/11557482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.10.2865-2870.2001
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