Isolation of Rat Dihydrofolate Reductase Gene and Characterization of Recombinant Enzyme

While assays of many antifolate inhibitors for dihydrofolate reductase (DHFR) have been performed using rat DHFR as a target, neither the sequence nor the structure of rat DHFR is known. Here, we report the isolation of the rat DHFR gene through screening of a rat liver cDNA library. The rat liver D...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Wang, Yangzhou, Bruenn, Jeremy A., Queener, Sherry F., Cody, Vivian
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2001
Soggetti:	Mechanisms of Action: Physiological Effects
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90686/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11502523/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.9.2517-2523.2001
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