Development of a Yeast Assay for Rapid Screening of Inhibitors of Human-Derived Pneumocystis carinii Dihydrofolate Reductase

Human-derived Pneumocystis carinii dihydrofolate reductase (DHFR) was expressed in a Saccharomyces cerevisiae strain whose growth depends on complementation by this enzyme. We utilized a quantitative assay to measure the sensitivity of this yeast strain to DHFR inhibitors. This assay should be usefu...

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Εκδόθηκε σε:	Antimicrob Agents Chemother
Κύριοι συγγραφείς:	Ma, Liang, Jia, Qiuyao, Kovacs, Joseph A.
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	American Society for Microbiology (ASM) 2002
Θέματα:	Mechanisms of Action: Physiological Effects
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127411/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12183283/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.9.3101-3103.2002
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