Development of a Yeast Assay for Rapid Screening of Inhibitors of Human-Derived Pneumocystis carinii Dihydrofolate Reductase
Human-derived Pneumocystis carinii dihydrofolate reductase (DHFR) was expressed in a Saccharomyces cerevisiae strain whose growth depends on complementation by this enzyme. We utilized a quantitative assay to measure the sensitivity of this yeast strain to DHFR inhibitors. This assay should be usefu...
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| Опубліковано в:: | Antimicrob Agents Chemother |
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| Автори: | , , |
| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
American Society for Microbiology (ASM)
2002
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| Предмети: | |
| Онлайн доступ: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127411/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12183283/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.9.3101-3103.2002 |
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