Type II Topoisomerase Mutations in Fluoroquinolone-Resistant Clinical Strains of Pseudomonas aeruginosa Isolated in 1998 and 1999: Role of Target Enzyme in Mechanism of Fluoroquinolone Resistance

The major mechanism of resistance to fluoroquinolones for Pseudomonas aeruginosa is the modification of type II topoisomerases (DNA gyrase and topoisomerase IV). We examined the mutations in quinolone-resistance-determining regions (QRDR) of gyrA, gyrB, parC, and parE genes of recent clinical isolat...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Akasaka, Takaaki, Tanaka, Mayumi, Yamaguchi, Akihito, Sato, Kenichi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2001
Assuntos:	Mechanisms of Resistance
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90640/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11451683/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.8.2263-2268.2001
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