Type II Topoisomerase Mutations in Fluoroquinolone-Resistant Clinical Strains of Pseudomonas aeruginosa Isolated in 1998 and 1999: Role of Target Enzyme in Mechanism of Fluoroquinolone Resistance

The major mechanism of resistance to fluoroquinolones for Pseudomonas aeruginosa is the modification of type II topoisomerases (DNA gyrase and topoisomerase IV). We examined the mutations in quinolone-resistance-determining regions (QRDR) of gyrA, gyrB, parC, and parE genes of recent clinical isolat...

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Bibliografiske detaljer
Main Authors: Akasaka, Takaaki, Tanaka, Mayumi, Yamaguchi, Akihito, Sato, Kenichi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2001
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC90640/
https://ncbi.nlm.nih.gov/pubmed/11451683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.8.2263-2268.2001
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