Type II Topoisomerase Mutations in Fluoroquinolone-Resistant Clinical Strains of Pseudomonas aeruginosa Isolated in 1998 and 1999: Role of Target Enzyme in Mechanism of Fluoroquinolone Resistance

The major mechanism of resistance to fluoroquinolones for Pseudomonas aeruginosa is the modification of type II topoisomerases (DNA gyrase and topoisomerase IV). We examined the mutations in quinolone-resistance-determining regions (QRDR) of gyrA, gyrB, parC, and parE genes of recent clinical isolat...

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Autores principales: Akasaka, Takaaki, Tanaka, Mayumi, Yamaguchi, Akihito, Sato, Kenichi
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2001
Materias:
Mechanisms of Resistance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC90640/
https://ncbi.nlm.nih.gov/pubmed/11451683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.8.2263-2268.2001
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