Antibacterial Activities and Inhibitory Effects of Sitafloxacin (DU-6859a) and Its Optical Isomers against Type II Topoisomerases

The in vitro inhibitory effects of sitafloxacin (DU-6859a) and its three stereoisomers on bacterial DNA gyrase from Escherichia coli, topoisomerase IV from Staphylococcus aureus, and topoisomerase II from human placenta were compared. No correlation was observed between the inhibitory activities of...

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Main Authors: Akasaka, Takaaki, Kurosaka, Seiko, Uchida, Yoko, Tanaka, Mayumi, Sato, Kenichi, Hayakawa, Isao
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 1998
Teme:
Mechanisms of Action: Physiological Effects
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC105807/
https://ncbi.nlm.nih.gov/pubmed/9593169
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