Peptide Deformylase as an Antibacterial Drug Target: Target Validation and Resistance Development

New inhibitors of peptide deformylase (PDF) which are very potent against the isolated enzyme and show a certain degree of antibacterial activity have recently been synthesized by our group. Several lines of experimental evidence indicate that these inhibitors indeed interfere with the target enzyme...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Apfel, Christian M., Locher, Hans, Evers, Stefan, Takács, Béla, Hubschwerlen, Christian, Pirson, Wolfgang, Page, Malcolm G. P., Keck, Wolfgang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2001
Pynciau:
Mechanisms of Action: Physiological Effects
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC90425/
https://ncbi.nlm.nih.gov/pubmed/11257016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.4.1058-1064.2001
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