Peptide Deformylase as an Antibacterial Drug Target: Assays for Detection of Its Inhibition in Escherichia coli Cell Homogenates and Intact Cells

An assay was developed to determine the activity of peptide deformylase (PDF) inhibitors under conditions as close as possible to the physiological situation. The assay principle is the detection of N-terminal [(35)S]methionine labeling of a protein that contains no internal methionine. If PDF is ac...

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ग्रंथसूची विवरण

में प्रकाशित:	Antimicrob Agents Chemother
मुख्य लेखकों:	Apfel, Christian M., Evers, Stefan, Hubschwerlen, Christian, Pirson, Wolfgang, Page, Malcolm G. P., Keck, Wolfgang
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	American Society for Microbiology (ASM) 2001
विषय:	Mechanisms of Action: Physiological Effects
ऑनलाइन पहुंच:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90424/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11257015/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.4.1053-1057.2001
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