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Kinetic control of nascent protein biogenesis by peptide deformylase

Abstract Synthesis of bacterial proteins on the ribosome starts with a formylated methionine. Removal of the N-terminal formyl group is essential and is carried out by peptide deformylase (PDF). Deformylation occurs co-translationally, shortly after the nascent-chain emerges from the ribosomal exit...

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Principais autores: Lena A. K. Bögeholz, Evan Mercier, Wolfgang Wintermeyer, Marina V. Rodnina
Formato: Artigo
Idioma:Inglês
Publicado: Nature Portfolio 2021-12-01
Series:Scientific Reports
Acceso en liña:https://doi.org/10.1038/s41598-021-03969-3
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