N-Alkyl Urea Hydroxamic Acids as a New Class of Peptide Deformylase Inhibitors with Antibacterial Activity

Peptide deformylase (PDF) is a prokaryotic metalloenzyme that is essential for bacterial growth and is a new target for the development of antibacterial agents. All previously reported PDF inhibitors with sufficient antibacterial activity share the structural feature of a 2-substituted alkanoyl at t...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Hackbarth, Corinne J., Chen, Dawn Z., Lewis, Jason G., Clark, Kirk, Mangold, James B., Cramer, Jeffrey A., Margolis, Peter S., Wang, Wen, Koehn, Jim, Wu, Charlotte, Lopez, S., Withers III, George, Gu, Helen, Dunn, Elina, Kulathila, R., Pan, Shi-Hao, Porter, Wilma L., Jacobs, Jeff, Trias, Joaquim, Patel, Dinesh V., Weidmann, Beat, White, Richard J., Yuan, Zhengyu
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2002
Gaiak:
Mechanisms of Action: Physiological Effects
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC127453/
https://ncbi.nlm.nih.gov/pubmed/12183225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.9.2752-2764.2002
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