N-Alkyl Urea Hydroxamic Acids as a New Class of Peptide Deformylase Inhibitors with Antibacterial Activity

Peptide deformylase (PDF) is a prokaryotic metalloenzyme that is essential for bacterial growth and is a new target for the development of antibacterial agents. All previously reported PDF inhibitors with sufficient antibacterial activity share the structural feature of a 2-substituted alkanoyl at t...

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প্রকাশিত:	Antimicrob Agents Chemother
প্রধান লেখক:	Hackbarth, Corinne J., Chen, Dawn Z., Lewis, Jason G., Clark, Kirk, Mangold, James B., Cramer, Jeffrey A., Margolis, Peter S., Wang, Wen, Koehn, Jim, Wu, Charlotte, Lopez, S., Withers III, George, Gu, Helen, Dunn, Elina, Kulathila, R., Pan, Shi-Hao, Porter, Wilma L., Jacobs, Jeff, Trias, Joaquim, Patel, Dinesh V., Weidmann, Beat, White, Richard J., Yuan, Zhengyu
বিন্যাস:	Artigo
ভাষা:	Inglês
প্রকাশিত:	American Society for Microbiology (ASM) 2002
বিষয়গুলি:	Mechanisms of Action: Physiological Effects
অনলাইন ব্যবহার করুন:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127453/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12183225/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.9.2752-2764.2002
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