N-Alkyl Urea Hydroxamic Acids as a New Class of Peptide Deformylase Inhibitors with Antibacterial Activity

Peptide deformylase (PDF) is a prokaryotic metalloenzyme that is essential for bacterial growth and is a new target for the development of antibacterial agents. All previously reported PDF inhibitors with sufficient antibacterial activity share the structural feature of a 2-substituted alkanoyl at t...

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Бібліографічні деталі
Опубліковано в::	Antimicrob Agents Chemother
Автори:	Hackbarth, Corinne J., Chen, Dawn Z., Lewis, Jason G., Clark, Kirk, Mangold, James B., Cramer, Jeffrey A., Margolis, Peter S., Wang, Wen, Koehn, Jim, Wu, Charlotte, Lopez, S., Withers III, George, Gu, Helen, Dunn, Elina, Kulathila, R., Pan, Shi-Hao, Porter, Wilma L., Jacobs, Jeff, Trias, Joaquim, Patel, Dinesh V., Weidmann, Beat, White, Richard J., Yuan, Zhengyu
Формат:	Artigo
Мова:	Inglês
Опубліковано:	American Society for Microbiology (ASM) 2002
Предмети:	Mechanisms of Action: Physiological Effects
Онлайн доступ:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127453/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12183225/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.9.2752-2764.2002
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N-Alkyl Urea Hydroxamic Acids as a New Class of Peptide Deformylase Inhibitors with Antibacterial Activity

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