N-Alkyl Urea Hydroxamic Acids as a New Class of Peptide Deformylase Inhibitors with Antibacterial Activity

Peptide deformylase (PDF) is a prokaryotic metalloenzyme that is essential for bacterial growth and is a new target for the development of antibacterial agents. All previously reported PDF inhibitors with sufficient antibacterial activity share the structural feature of a 2-substituted alkanoyl at t...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Hackbarth, Corinne J., Chen, Dawn Z., Lewis, Jason G., Clark, Kirk, Mangold, James B., Cramer, Jeffrey A., Margolis, Peter S., Wang, Wen, Koehn, Jim, Wu, Charlotte, Lopez, S., Withers III, George, Gu, Helen, Dunn, Elina, Kulathila, R., Pan, Shi-Hao, Porter, Wilma L., Jacobs, Jeff, Trias, Joaquim, Patel, Dinesh V., Weidmann, Beat, White, Richard J., Yuan, Zhengyu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2002
Assuntos:	Mechanisms of Action: Physiological Effects
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127453/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12183225/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.9.2752-2764.2002
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