Peptide Deformylase as an Antibacterial Drug Target: Target Validation and Resistance Development

New inhibitors of peptide deformylase (PDF) which are very potent against the isolated enzyme and show a certain degree of antibacterial activity have recently been synthesized by our group. Several lines of experimental evidence indicate that these inhibitors indeed interfere with the target enzyme...

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Detalhes bibliográficos
Main Authors: Apfel, Christian M., Locher, Hans, Evers, Stefan, Takács, Béla, Hubschwerlen, Christian, Pirson, Wolfgang, Page, Malcolm G. P., Keck, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC90425/
https://ncbi.nlm.nih.gov/pubmed/11257016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.4.1058-1064.2001
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