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In Vivo Effect of α(1)-Acid Glycoprotein on Pharmacokinetics of Amprenavir, a Human Immunodeficiency Virus Protease Inhibitor

Observations from early clinical pharmacology studies of amprenavir, an inhibitor of human immunodeficiency virus type 1 (HIV-1) protease that is highly bound to human plasma proteins (∼90%), showed the single-dose pharmacokinetics of amprenavir to be variable between and within individuals. A cross...

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Bibliografiske detaljer
Main Authors: Sadler, Brian M., Gillotin, Catherine, Lou, Yu, Stein, Daniel S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2001
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC90384/
https://ncbi.nlm.nih.gov/pubmed/11181371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.3.852-856.2001
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