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In Vivo Effect of α(1)-Acid Glycoprotein on Pharmacokinetics of Amprenavir, a Human Immunodeficiency Virus Protease Inhibitor
Observations from early clinical pharmacology studies of amprenavir, an inhibitor of human immunodeficiency virus type 1 (HIV-1) protease that is highly bound to human plasma proteins (∼90%), showed the single-dose pharmacokinetics of amprenavir to be variable between and within individuals. A cross...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Microbiology
2001
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC90384/ https://ncbi.nlm.nih.gov/pubmed/11181371 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.3.852-856.2001 |
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