Pharmacokinetic Interaction between Amprenavir and Clarithromycin in Healthy Male Volunteers

The P450 enzyme, CYP3A4, extensively metabolizes both amprenavir and clarithromycin. To determine if an interaction exists when these two drugs are coadministered, the pharmacokinetics of amprenavir and clarithromycin were investigated in healthy adult male volunteers. This was a Phase I, open-label...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Brophy, Donald F., Israel, Debra S., Pastor, Antonio, Gillotin, Catherine, Chittick, Greg E., Symonds, William T., Lou, Yu, Sadler, Brian M., Polk, Ron E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2000
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC89801/
https://ncbi.nlm.nih.gov/pubmed/10722500
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge