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Pharmacokinetic Interaction between Amprenavir and Clarithromycin in Healthy Male Volunteers

The P450 enzyme, CYP3A4, extensively metabolizes both amprenavir and clarithromycin. To determine if an interaction exists when these two drugs are coadministered, the pharmacokinetics of amprenavir and clarithromycin were investigated in healthy adult male volunteers. This was a Phase I, open-label...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Brophy, Donald F., Israel, Debra S., Pastor, Antonio, Gillotin, Catherine, Chittick, Greg E., Symonds, William T., Lou, Yu, Sadler, Brian M., Polk, Ron E.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology 2000
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC89801/
https://ncbi.nlm.nih.gov/pubmed/10722500
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