Pharmacokinetic Interaction between Amprenavir and Clarithromycin in Healthy Male Volunteers

The P450 enzyme, CYP3A4, extensively metabolizes both amprenavir and clarithromycin. To determine if an interaction exists when these two drugs are coadministered, the pharmacokinetics of amprenavir and clarithromycin were investigated in healthy adult male volunteers. This was a Phase I, open-label...

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Main Authors: Brophy, Donald F., Israel, Debra S., Pastor, Antonio, Gillotin, Catherine, Chittick, Greg E., Symonds, William T., Lou, Yu, Sadler, Brian M., Polk, Ron E.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2000
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC89801/
https://ncbi.nlm.nih.gov/pubmed/10722500
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