Pharmacokinetic Interaction between Amprenavir and Clarithromycin in Healthy Male Volunteers

The P450 enzyme, CYP3A4, extensively metabolizes both amprenavir and clarithromycin. To determine if an interaction exists when these two drugs are coadministered, the pharmacokinetics of amprenavir and clarithromycin were investigated in healthy adult male volunteers. This was a Phase I, open-label...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Brophy, Donald F., Israel, Debra S., Pastor, Antonio, Gillotin, Catherine, Chittick, Greg E., Symonds, William T., Lou, Yu, Sadler, Brian M., Polk, Ron E.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Pharmacology
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89801/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10722500/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.4.978-984.2000
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