Pharmacokinetic Interaction between Amprenavir and Clarithromycin in Healthy Male Volunteers

The P450 enzyme, CYP3A4, extensively metabolizes both amprenavir and clarithromycin. To determine if an interaction exists when these two drugs are coadministered, the pharmacokinetics of amprenavir and clarithromycin were investigated in healthy adult male volunteers. This was a Phase I, open-label...

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Main Authors: Brophy, Donald F., Israel, Debra S., Pastor, Antonio, Gillotin, Catherine, Chittick, Greg E., Symonds, William T., Lou, Yu, Sadler, Brian M., Polk, Ron E.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2000
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC89801/
https://ncbi.nlm.nih.gov/pubmed/10722500
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