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Bioavailability and Preliminary Clinical Efficacy of Intrarectal Artesunate in Ghanaian Children with Moderate Malaria

We report the first detailed pharmacokinetic assessment of intrarectal (i.r.) artesunate (ARS) in African children. Artesunate was given intravenously (i.v.; 2.4 mg/kg of body weight) and i.r. (10 or 20 mg/kg formulated as 50- or 200-mg suppositories [Rectocaps]) in a crossover study design to 34 Gh...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Principais autores: Krishna, Sanjeev, Planche, Tim, Agbenyega, Tsiri, Woodrow, Charles, Agranoff, Dan, Bedu-Addo, George, Owusu-Ofori, Alex K., Appiah, John Adabie, Ramanathan, Surash, Mansor, Sharif M., Navaratnam, Visweswaran
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2001
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Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90320/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11158748/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.2.509-516.2001
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