Bioavailability and Preliminary Clinical Efficacy of Intrarectal Artesunate in Ghanaian Children with Moderate Malaria

We report the first detailed pharmacokinetic assessment of intrarectal (i.r.) artesunate (ARS) in African children. Artesunate was given intravenously (i.v.; 2.4 mg/kg of body weight) and i.r. (10 or 20 mg/kg formulated as 50- or 200-mg suppositories [Rectocaps]) in a crossover study design to 34 Gh...

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Detalhes bibliográficos
Main Authors: Krishna, Sanjeev, Planche, Tim, Agbenyega, Tsiri, Woodrow, Charles, Agranoff, Dan, Bedu-Addo, George, Owusu-Ofori, Alex K., Appiah, John Adabie, Ramanathan, Surash, Mansor, Sharif M., Navaratnam, Visweswaran
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC90320/
https://ncbi.nlm.nih.gov/pubmed/11158748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.2.509-516.2001
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