Bioavailability and Preliminary Clinical Efficacy of Intrarectal Artesunate in Ghanaian Children with Moderate Malaria

We report the first detailed pharmacokinetic assessment of intrarectal (i.r.) artesunate (ARS) in African children. Artesunate was given intravenously (i.v.; 2.4 mg/kg of body weight) and i.r. (10 or 20 mg/kg formulated as 50- or 200-mg suppositories [Rectocaps]) in a crossover study design to 34 Gh...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Εκδόθηκε σε:	Antimicrob Agents Chemother
Κύριοι συγγραφείς:	Krishna, Sanjeev, Planche, Tim, Agbenyega, Tsiri, Woodrow, Charles, Agranoff, Dan, Bedu-Addo, George, Owusu-Ofori, Alex K., Appiah, John Adabie, Ramanathan, Surash, Mansor, Sharif M., Navaratnam, Visweswaran
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	American Society for Microbiology (ASM) 2001
Θέματα:	Pharmacology
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90320/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11158748/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.2.509-516.2001
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