Bioavailability and Preliminary Clinical Efficacy of Intrarectal Artesunate in Ghanaian Children with Moderate Malaria

We report the first detailed pharmacokinetic assessment of intrarectal (i.r.) artesunate (ARS) in African children. Artesunate was given intravenously (i.v.; 2.4 mg/kg of body weight) and i.r. (10 or 20 mg/kg formulated as 50- or 200-mg suppositories [Rectocaps]) in a crossover study design to 34 Gh...

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Dades bibliogràfiques

Publicat a:	Antimicrob Agents Chemother
Autors principals:	Krishna, Sanjeev, Planche, Tim, Agbenyega, Tsiri, Woodrow, Charles, Agranoff, Dan, Bedu-Addo, George, Owusu-Ofori, Alex K., Appiah, John Adabie, Ramanathan, Surash, Mansor, Sharif M., Navaratnam, Visweswaran
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology (ASM) 2001
Matèries:	Pharmacology
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90320/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11158748/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.2.509-516.2001
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