Identification of Cryptosporidium parvum Dihydrofolate Reductase Inhibitors by Complementation in Saccharomyces cerevisiae

There is a pressing need for drugs effective against the opportunistic protozoan pathogen Cryptosporidium parvum. Folate metabolic enzymes and enzymes of the thymidylate cycle, particularly dihydrofolate reductase (DHFR), have been widely exploited as chemotherapeutic targets. Although many DHFR inh...

Full description

Saved in:
Bibliographic Details
Main Authors: Brophy, Victoria Hertle, Vasquez, John, Nelson, Richard G., Forney, John R., Rosowsky, Andre, Sibley, Carol Hopkins
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Susceptibility
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC89807/
https://ncbi.nlm.nih.gov/pubmed/10722506
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items