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Identification of Cryptosporidium parvum Dihydrofolate Reductase Inhibitors by Complementation in Saccharomyces cerevisiae

There is a pressing need for drugs effective against the opportunistic protozoan pathogen Cryptosporidium parvum. Folate metabolic enzymes and enzymes of the thymidylate cycle, particularly dihydrofolate reductase (DHFR), have been widely exploited as chemotherapeutic targets. Although many DHFR inh...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Brophy, Victoria Hertle, Vasquez, John, Nelson, Richard G., Forney, John R., Rosowsky, Andre, Sibley, Carol Hopkins
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2000
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC89807/
https://ncbi.nlm.nih.gov/pubmed/10722506
Tagiau: Ychwanegu Tag
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