Identification of Cryptosporidium parvum Dihydrofolate Reductase Inhibitors by Complementation in Saccharomyces cerevisiae

There is a pressing need for drugs effective against the opportunistic protozoan pathogen Cryptosporidium parvum. Folate metabolic enzymes and enzymes of the thymidylate cycle, particularly dihydrofolate reductase (DHFR), have been widely exploited as chemotherapeutic targets. Although many DHFR inh...

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Main Authors: Brophy, Victoria Hertle, Vasquez, John, Nelson, Richard G., Forney, John R., Rosowsky, Andre, Sibley, Carol Hopkins
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2000
Teme:
Susceptibility
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC89807/
https://ncbi.nlm.nih.gov/pubmed/10722506
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