Intracellular Metabolism of β-l-2′,3′-Dideoxyadenosine: Relevance to Its Limited Antiviral Activity

The intracellular metabolism of the β-l- enantiomer of 2′,3′-dideoxyadenosine (β-l-ddA) was investigated in HepG2 cells, human peripheral blood mononuclear cells (PBMC), and primary cultured human hepatocytes in an effort to understand the metabolic basis of its limited activity on the replication o...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Placidi, Laurent, Cretton-Scott, Erika, Gosselin, Gilles, Pierra, Claire, Schinazi, Raymond F., Imbach, Jean-Louis, el Kouni, Mahmoud H., Sommadossi, Jean-Pierre
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2000
Schlagworte:	Antiviral Agents
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89782/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10722481/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.4.853-858.2000
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