Intracellular Metabolism of β-l-2′,3′-Dideoxyadenosine: Relevance to Its Limited Antiviral Activity

The intracellular metabolism of the β-l- enantiomer of 2′,3′-dideoxyadenosine (β-l-ddA) was investigated in HepG2 cells, human peripheral blood mononuclear cells (PBMC), and primary cultured human hepatocytes in an effort to understand the metabolic basis of its limited activity on the replication o...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Placidi, Laurent, Cretton-Scott, Erika, Gosselin, Gilles, Pierra, Claire, Schinazi, Raymond F., Imbach, Jean-Louis, el Kouni, Mahmoud H., Sommadossi, Jean-Pierre
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Antiviral Agents
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89782/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10722481/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.4.853-858.2000
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