Intracellular Metabolism of β-l-2′,3′-Dideoxyadenosine: Relevance to Its Limited Antiviral Activity

The intracellular metabolism of the β-l- enantiomer of 2′,3′-dideoxyadenosine (β-l-ddA) was investigated in HepG2 cells, human peripheral blood mononuclear cells (PBMC), and primary cultured human hepatocytes in an effort to understand the metabolic basis of its limited activity on the replication o...

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Autores principales: Placidi, Laurent, Cretton-Scott, Erika, Gosselin, Gilles, Pierra, Claire, Schinazi, Raymond F., Imbach, Jean-Louis, el Kouni, Mahmoud H., Sommadossi, Jean-Pierre
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2000
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC89782/
https://ncbi.nlm.nih.gov/pubmed/10722481
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