Single-Dose Pharmacokinetics of Amprenavir, a Human Immunodeficiency Virus Type 1 Protease Inhibitor, in Subjects with Normal or Impaired Hepatic Function

Amprenavir (141W94) is extensively metabolized by P450 cytochromes, specifically, CYP3A4. Because hepatic insufficiency reduces P450-mediated metabolism, the concentrations in plasma of drugs metabolized through this pathway are often increased in subjects with liver disease. Following administratio...

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Main Authors: Veronese, Laurence, Rautaureau, Jacques, Sadler, Brian M., Gillotin, Catherine, Petite, Jean-Pierre, Pillegand, Bernard, Delvaux, Michel, Masliah, Claude, Fosse, Sandrine, Lou, Yu, Stein, Daniel S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2000
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC89777/
https://ncbi.nlm.nih.gov/pubmed/10722476
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