Single-Dose Pharmacokinetics of Amprenavir, a Human Immunodeficiency Virus Type 1 Protease Inhibitor, in Subjects with Normal or Impaired Hepatic Function

Amprenavir (141W94) is extensively metabolized by P450 cytochromes, specifically, CYP3A4. Because hepatic insufficiency reduces P450-mediated metabolism, the concentrations in plasma of drugs metabolized through this pathway are often increased in subjects with liver disease. Following administratio...

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הוצא לאור ב:	Antimicrob Agents Chemother
Principais autores:	Veronese, Laurence, Rautaureau, Jacques, Sadler, Brian M., Gillotin, Catherine, Petite, Jean-Pierre, Pillegand, Bernard, Delvaux, Michel, Masliah, Claude, Fosse, Sandrine, Lou, Yu, Stein, Daniel S.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	American Society for Microbiology (ASM) 2000
נושאים:	Pharmacology
גישה מקוונת:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89777/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10722476/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.4.821-826.2000
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