Immunosuppressive and Nonimmunosuppressive Cyclosporine Analogs Are Toxic to the Opportunistic Fungal Pathogen Cryptococcus neoformans via Cyclophilin-Dependent Inhibition of Calcineurin

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• The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein.
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  Cyhoeddwyd: (1997)
• Calcineurin is required for virulence of Cryptococcus neoformans.
  gan: Odom, A, et al.
  Cyhoeddwyd: (1997)
• Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus (HIV) type 1: interference with HIV protein-cyclophilin A interactions.
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  Cyhoeddwyd: (1995)
• A Calcineurin-Independent Mechanism of Angiogenesis Inhibition by a Nonimmunosuppressive Cyclosporin A Analog
  gan: Nacev, Benjamin A., et al.
  Cyhoeddwyd: (2011)
• Rapamycin and Less Immunosuppressive Analogs Are Toxic to Candida albicans and Cryptococcus neoformans via FKBP12-Dependent Inhibition of TOR
  gan: Cruz, M. Cristina, et al.
  Cyhoeddwyd: (2001)