Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs

ABSTRACT Calcineurin is a critical enzyme in fungal pathogenesis and antifungal drug tolerance and, therefore, an attractive antifungal target. Current clinically accessible calcineurin inhibitors, such as FK506, are immunosuppressive to humans, so exploiting calcineurin inhibition as an antifungal...

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Autori principali:	Sophie M.-C. Gobeil, Benjamin G. Bobay, Praveen R. Juvvadi, D. Christopher Cole, Joseph Heitman, William J. Steinbach, Ronald A. Venters, Leonard D. Spicer
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology 2021-12-01
Serie:	mBio
Soggetti:	FK506 FKBP12 APX879 antifungals M. circinelloides A. fumigatus
Accesso online:	https://journals.asm.org/doi/10.1128/mBio.03000-21
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