Immunosuppressive and Nonimmunosuppressive Cyclosporine Analogs Are Toxic to the Opportunistic Fungal Pathogen Cryptococcus neoformans via Cyclophilin-Dependent Inhibition of Calcineurin

Cyclosporine (CsA) is an immunosuppressive and antimicrobial drug which, in complex with cyclophilin A, inhibits the protein phosphatase calcineurin. We recently found that Cryptococcus neoformans growth is resistant to CsA at 24°C but sensitive at 37°C and that calcineurin is required for growth at...

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Detalhes bibliográficos
Main Authors: Cruz, M. Cristina, Del Poeta, Maurizio, Wang, Ping, Wenger, Roland, Zenke, Gerhard, Quesniaux, Valerie F. J., Movva, N. Rao, Perfect, John R., Cardenas, Maria E., Heitman, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC89641/
https://ncbi.nlm.nih.gov/pubmed/10602736
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