Immunosuppressive and Nonimmunosuppressive Cyclosporine Analogs Are Toxic to the Opportunistic Fungal Pathogen Cryptococcus neoformans via Cyclophilin-Dependent Inhibition of Calcineurin

Antzeko izenburuak

• The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein.
  nork: Odom, A, et al.
  Argitaratua: (1997)
• Calcineurin is required for virulence of Cryptococcus neoformans.
  nork: Odom, A, et al.
  Argitaratua: (1997)
• Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus (HIV) type 1: interference with HIV protein-cyclophilin A interactions.
  nork: Billich, A, et al.
  Argitaratua: (1995)
• A Calcineurin-Independent Mechanism of Angiogenesis Inhibition by a Nonimmunosuppressive Cyclosporin A Analog
  nork: Nacev, Benjamin A., et al.
  Argitaratua: (2011)
• Rapamycin and Less Immunosuppressive Analogs Are Toxic to Candida albicans and Cryptococcus neoformans via FKBP12-Dependent Inhibition of TOR
  nork: Cruz, M. Cristina, et al.
  Argitaratua: (2001)