Immunosuppressive and Nonimmunosuppressive Cyclosporine Analogs Are Toxic to the Opportunistic Fungal Pathogen Cryptococcus neoformans via Cyclophilin-Dependent Inhibition of Calcineurin

Cyclosporine (CsA) is an immunosuppressive and antimicrobial drug which, in complex with cyclophilin A, inhibits the protein phosphatase calcineurin. We recently found that Cryptococcus neoformans growth is resistant to CsA at 24°C but sensitive at 37°C and that calcineurin is required for growth at...

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التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Antimicrob Agents Chemother
المؤلفون الرئيسيون:	Cruz, M. Cristina, Del Poeta, Maurizio, Wang, Ping, Wenger, Roland, Zenke, Gerhard, Quesniaux, Valerie F. J., Movva, N. Rao, Perfect, John R., Cardenas, Maria E., Heitman, Joseph
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	American Society for Microbiology (ASM) 2000
الموضوعات:	Mechanisms of Action: Physiological Effects
الوصول للمادة أونلاين:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89641/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10602736/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.1.143-149.2000
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