Contribution of Topoisomerase IV and DNA Gyrase Mutations in Streptococcus pneumoniae to Resistance to Novel Fluoroquinolones

In this study, we assessed the activity of ciprofloxacin, levofloxacin, sparfloxacin, and trovafloxacin against clinical isolates of Streptococcus pneumoniae that were resistant to the less-recently developed fluoroquinolones by using defined amino acid substitutions in DNA gyrase and topoisomerase...

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Bibliographic Details
Main Authors: Pestova, Ekaterina, Beyer, Rebecca, Cianciotto, Nicholas P., Noskin, Gary A., Peterson, Lance R.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC89404/
https://ncbi.nlm.nih.gov/pubmed/10428926
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