Contribution of Topoisomerase IV and DNA Gyrase Mutations in Streptococcus pneumoniae to Resistance to Novel Fluoroquinolones

In this study, we assessed the activity of ciprofloxacin, levofloxacin, sparfloxacin, and trovafloxacin against clinical isolates of Streptococcus pneumoniae that were resistant to the less-recently developed fluoroquinolones by using defined amino acid substitutions in DNA gyrase and topoisomerase...

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Библиографические подробности
Главные авторы: Pestova, Ekaterina, Beyer, Rebecca, Cianciotto, Nicholas P., Noskin, Gary A., Peterson, Lance R.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 1999
Предметы:
Mechanisms of Resistance
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC89404/
https://ncbi.nlm.nih.gov/pubmed/10428926
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