A Convenient Assay for Estimating the Possible Involvement of Efflux of Fluoroquinolones by Streptococcus pneumoniae and Staphylococcus aureus: Evidence for Diminished Moxifloxacin, Sparfloxacin, and Trovafloxacin Efflux

We developed a simplified assay for estimating efflux by measuring the effect of reserpine on the growth of Streptococcus pneumoniae and Staphylococcus aureus over 7 h. Reserpine enhanced ciprofloxacin and levofloxacin 17 to 68%. The hydrophobic drug trovafloxacin and the drug moxifloxacin, with a b...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Beyer, Rebecca, Pestova, Ekaterina, Millichap, John J., Stosor, Valentina, Noskin, Gary A., Peterson, Lance R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Mechanisms of Resistance
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89772/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10681364/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.3.798-801.2000
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