Contribution of Topoisomerase IV and DNA Gyrase Mutations in Streptococcus pneumoniae to Resistance to Novel Fluoroquinolones

In this study, we assessed the activity of ciprofloxacin, levofloxacin, sparfloxacin, and trovafloxacin against clinical isolates of Streptococcus pneumoniae that were resistant to the less-recently developed fluoroquinolones by using defined amino acid substitutions in DNA gyrase and topoisomerase...

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Detalles Bibliográficos

Publicado en:	Antimicrob Agents Chemother
Principais autores:	Pestova, Ekaterina, Beyer, Rebecca, Cianciotto, Nicholas P., Noskin, Gary A., Peterson, Lance R.
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 1999
Assuntos:	Mechanisms of Resistance
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89404/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10428926/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.8.2000
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