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Anti-Human Immunodeficiency Virus Type 1 Activity, Intracellular Metabolism, and Pharmacokinetic Evaluation of 2′-Deoxy-3′-Oxa-4′-Thiocytidine

The racemic nucleoside analogue 2′-deoxy-3′-oxa-4′-thiocytidine (dOTC) is in clinical development for the treatment of human immunodeficiency virus (HIV) type 1 (HIV-1) infection. dOTC is structurally related to lamivudine (3TC), but the oxygen and sulfur in the furanosyl ring are transposed. Intrac...

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Published in:Antimicrob Agents Chemother
Main Authors: de Muys, Jean-Marc, Gourdeau, Henriette, Nguyen-Ba, Nghe, Taylor, Debra L., Ahmed, Parvin S., Mansour, Tarek, Locas, Celine, Richard, Nathalie, Wainberg, Mark A., Rando, Robert F.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1999
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89378/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10428900/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.8.1835
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