Antiviral Activity of 2′-Deoxy-3′-Oxa-4′-Thiocytidine (BCH-10652) against Lamivudine-Resistant Human Immunodeficiency Virus Type 1 in SCID-hu Thy/Liv Mice

Oral administration of 2′-deoxy-3′-oxa-4′-thiocytidine (BCH-10652), a nucleoside analog structurally similar to lamivudine (3TC), caused dose-dependent inhibition of viral replication in SCID-hu Thy/Liv mice infected with human immunodeficiency virus type 1 NL4-3 and with an NL4-3 clone containing t...

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Main Authors: Stoddart, Cheryl A., Moreno, Mary E., Linquist-Stepps, Valerie D., Bare, Christopher, Bogan, Mark R., Gobbi, Alberto, Buckheit, Robert W., Bedard, Jean, Rando, Robert F., McCune, Joseph M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2000
Teme:
Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC89768/
https://ncbi.nlm.nih.gov/pubmed/10681360
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