Tumor-Specific Proteolytic Processing of Cyclin E Generates Hyperactive Lower-Molecular-Weight Forms

Cyclin E is a G(1) cyclin essential for S-phase entry and has a profound role in oncogenesis. Previously this laboratory found that cyclin E is overexpressed and present in lower-molecular-weight (LMW) isoforms in breast cancer cells and tumor tissues compared to normal cells and tissues. Such alter...

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Detalhes bibliográficos
Main Authors: Porter, Donald C., Zhang, Ning, Danes, Christopher, McGahren, Mollianne J., Harwell, Richard M., Faruki, Shamsa, Keyomarsi, Khandan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC87349/
https://ncbi.nlm.nih.gov/pubmed/11509668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.18.6254-6269.2001
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