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Cdk2 is required for breast cancer mediated by the low molecular weight isoform of cyclin E
Cyclin E activates Cdk2, controls centrosome duplication and regulates histone gene transcription. Cyclin E is deregulated in cancer and appears as low molecular weight (LMW) isoforms that correlate strongly with decreased survival in breast cancer patients. Transgenic mice overexpressing LMW cyclin...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3085722/ https://ncbi.nlm.nih.gov/pubmed/21385896 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-4086 |
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