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Staurosporine is chemoprotective by inducing G(1) arrest in a Chk1- and pRb-dependent manner

Chemotherapeutic agents have been the mainstay of cancer therapy for years. However, their effectiveness has been limited by toxicities they impart on normal cells. Staurosporine (ST) has been shown to arrest normal, but not breast cancer, cells in G(1). Therefore, ST may become a chemoprotective ag...

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Bibliografische gegevens
Hoofdauteurs: Murray, Mollianne McGahren, Bui, Tuyen, Smith, Michelle, Bagheri-Yarmand, Rozita, Wingate, Hannah, Hunt, Kelly K., Keyomarsi, Khandan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3786379/
https://ncbi.nlm.nih.gov/pubmed/23722650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgt186
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