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Cyclin E Overexpression Impairs Mitotic Progression Through Premature Activation of Cdc25C and Deregulation of Cyclin B/CDK1 and PLK1 Activities
The cyclin E-CDK2 complex accelerates entry into the S phase of the cell cycle and promotes polyploidy, which may contribute to genomic instability in cancer cells. The impact of low-molecular weight isoforms of cyclin E (LMW-E) overexpression on mitotic progression and its link to genomic instabili...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2946214/ https://ncbi.nlm.nih.gov/pubmed/20530684 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4095 |
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