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Cyclin E Overexpression Impairs Mitotic Progression Through Premature Activation of Cdc25C and Deregulation of Cyclin B/CDK1 and PLK1 Activities

The cyclin E-CDK2 complex accelerates entry into the S phase of the cell cycle and promotes polyploidy, which may contribute to genomic instability in cancer cells. The impact of low-molecular weight isoforms of cyclin E (LMW-E) overexpression on mitotic progression and its link to genomic instabili...

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Detalhes bibliográficos
Main Authors: Bagheri-Yarmand, Rozita, Nanos-Webb, Angela, Biernacka, Anna, Bui, Tuyen, Keyomarsi, Khandan
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946214/
https://ncbi.nlm.nih.gov/pubmed/20530684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4095
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