Reduced Hepatic Uptake and Intestinal Excretion of Organic Cations in Mice with a Targeted Disruption of the Organic Cation Transporter 1 (Oct1 [Slc22a1]) Gene

The polyspecific organic cation transporter 1 (OCT1 [SLC22A1]) mediates facilitated transport of small (hydrophilic) organic cations. OCT1 is localized at the basolateral membrane of epithelial cells in the liver, kidney, and intestine and could therefore be involved in the elimination of endogenous...

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Detalhes bibliográficos
Principais autores: Jonker, Johan W., Wagenaar, Els, Mol, Carla A. A. M., Buitelaar, Marije, Koepsell, Hermann, Smit, Johan W., Schinkel, Alfred H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC87269/
https://ncbi.nlm.nih.gov/pubmed/11463829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.16.5471-5477.2001
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