Deficiency in the Organic Cation Transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in Mice Abolishes Renal Secretion of Organic Cations

The polyspecific organic cation transporters 1 and 2 (Oct1 and -2) transport a broad range of substrates, including drugs, toxins, and endogenous compounds. Their strategic localization in the basolateral membrane of epithelial cells in the liver, intestine (Oct1), and kidney (Oct1 and Oct2) suggest...

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Detalhes bibliográficos
Main Authors: Jonker, Johan W., Wagenaar, Els, van Eijl, Sven, Schinkel, Alfred H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC207626/
https://ncbi.nlm.nih.gov/pubmed/14560032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.21.7902-7908.2003
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