Deficiency in the Organic Cation Transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in Mice Abolishes Renal Secretion of Organic Cations

The polyspecific organic cation transporters 1 and 2 (Oct1 and -2) transport a broad range of substrates, including drugs, toxins, and endogenous compounds. Their strategic localization in the basolateral membrane of epithelial cells in the liver, intestine (Oct1), and kidney (Oct1 and Oct2) suggest...

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Hlavní autoři: Jonker, Johan W., Wagenaar, Els, van Eijl, Sven, Schinkel, Alfred H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2003
Témata:
Mammalian Genetic Models with Minimal or Complex Phenotypes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC207626/
https://ncbi.nlm.nih.gov/pubmed/14560032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.21.7902-7908.2003
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